Differentiation of mouse embryonic stem cells into a defined neuronal lineage

Bibel, M. and Richter, J. and Schrenk, K. and Tucker, K. L. and Staiger, V. and Korte, M. and Goetz, M. and Barde, Y. -A.. (2004) Differentiation of mouse embryonic stem cells into a defined neuronal lineage. Nature neuroscience, Vol. 7, H. 9. pp. 1003-1009.

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Official URL: http://edoc.unibas.ch/dok/A5259506

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Although it has long been known that cultured embryonic stem cells can generate neurons, the lineage relationships with their immediate precursors remain unclear. We report here that selection of highly proliferative stem cells followed by treatment with retinoic acid generated essentially pure precursors that markers identified as Pax-6-positive radial glial cells. As they do in vivo, these cells went on to generate neurons with remarkably uniform biochemical and electrophysiological characteristics.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Barde)
UniBasel Contributors:Barde, Yves-Alain
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature America
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:21
Deposited On:22 Mar 2012 13:22

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