edoc

Epigenetic memory takes center stage in the survival strategy of malaria parasites

Voss, Till S. and Bozdech, Zbynek and Bártfai, Richárd. (2014) Epigenetic memory takes center stage in the survival strategy of malaria parasites. Current Opinion in Microbiology, Vol. 20. pp. 88-95.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6288971

Downloads: Statistics Overview

Abstract

Malaria parasites run through a complex life cycle in the vertebrate host and mosquito vector. This not only requires tightly controlled mechanisms to govern stage-specific gene expression but also necessitates effective strategies for survival under changing environmental conditions. In recent years, the combination of different -omics approaches and targeted functional studies highlighted that Plasmodium falciparum blood stage parasites use heterochromatin-based gene silencing as a unifying strategy for clonally variant expression of hundreds of genes. In this article, we describe the epigenetic control mechanisms that mediate alternative expression states of genes involved in antigenic variation, nutrient uptake and sexual conversion and discuss the relevance of this strategy for the survival and transmission of malaria parasites.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Gene Regulation (Voss)
UniBasel Contributors:Voss, Till S
Item Type:Article, refereed
Article Subtype:Book Review
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1369-5274
e-ISSN:1879-0364
Note:Publication type according to Uni Basel Research Database: Journal item
Related URLs:
Identification Number:
Last Modified:13 Oct 2017 07:56
Deposited On:07 Nov 2014 08:28

Repository Staff Only: item control page