edoc

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms

Andorfer, C. and Kress, Y. and Espinoza, M. and de Silva, R. and Tucker, K. L. and Barde, Y. -A. and Duff, K. and Davies, P.. (2003) Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. Journal of neurochemistry, Vol. 86, H. 3. pp. 582-590.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A5259509

Downloads: Statistics Overview

Abstract

Neurofibrillary tangles are composed of insoluble aggregates of the microtubule-associated protein tau. In Alzheimer's disease the accumulation of neurofibrillary tangles occurs in the absence of tau mutations. Here we present mice that develop pathology from non-mutant human tau, in the absence of other exogenous factors, including beta-amyloid. The pathology in these mice is Alzheimer-like, with hyperphosphorylated tau accumulating as aggregated paired helical filaments. This pathologic tau accumulates in the cell bodies and dendrites of neurons in a spatiotemporally relevant distribution.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Barde)
UniBasel Contributors:Barde, Yves-Alain
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-Blackwell
ISSN:0022-3042
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:21
Deposited On:22 Mar 2012 13:22

Repository Staff Only: item control page