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The Search for Antiaging Interventions : From Elixirs to Fasting Regimens

de Cabo, R. and Carmona-Gutierrez, D. and Bernier, M. and Hall, M. N. and Madeo, F.. (2014) The Search for Antiaging Interventions : From Elixirs to Fasting Regimens. Cell, 157 (7). pp. 1515-1526.

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Official URL: http://edoc.unibas.ch/dok/A6271964

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Abstract

The phenomenon of aging is an intrinsic feature of life. Accordingly, the possibility to manipulate it has fascinated humans likely since time immemorial. Recent evidence is shaping a picture where low caloric regimes and exercise may improve healthy senescence, and several pharmacological strategies have been suggested to counteract aging. Surprisingly, the most effective interventions proposed to date converge on only a few cellular processes, in particular nutrient signaling, mitochondrial efficiency, proteostasis, and autophagy. Here, we critically examine drugs and behaviors to which life- or healthspan-extending properties have been ascribed and discuss the underlying molecular mechanisms.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Article, refereed
Article Subtype:Book Review
Bibsysno:Link to catalogue
Publisher:Cell Press
ISSN:0092-8674
e-ISSN:1097-4172
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:09 Nov 2017 08:06
Deposited On:07 Nov 2014 08:28

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