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Biosynthesis and processing of endogenous BDNF : CNS neurons store and secrete BDNF, not pro-BDNF

Matsumoto, T. and Rauskolb, S. and Polack, M. and Klose, J. and Kolbeck, R. and Korte, M. and Barde, Y. -A.. (2008) Biosynthesis and processing of endogenous BDNF : CNS neurons store and secrete BDNF, not pro-BDNF. Nature neuroscience, Vol. 11, H. 2. pp. 131-133.

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Official URL: http://edoc.unibas.ch/dok/A5259498

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Abstract

Pro- and mature BDNF activate very different receptors and intracellular pathways, potentially leading to either neuronal death or survival. Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by excitatory input.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Barde)
UniBasel Contributors:Barde, Yves-Alain
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature America
ISSN:1097-6256
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:21
Deposited On:22 Mar 2012 13:22

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