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SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

Biasini, Marco and Bienert, Stefan and Waterhouse, Andrew and Arnold, Konstantin and Studer, Gabriel and Schmidt, Tobias and Kiefer, Florian and Cassarino, Tiziano Gallo and Bertoni, Martino and Bordoli, Lorenza and Schwede, Torsten. (2014) SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information. Nucleic Acids Research, 42 (W1). W252-W258.

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Official URL: http://edoc.unibas.ch/dok/A6263134

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Abstract

Protein structure homology modelling has become a routine technique to generate 3D models for proteins when experimental structures are not available. Fully automated servers such as SWISS-MODEL with user-friendly web interfaces generate reliable models without the need for complex software packages or downloading large databases. Here, we describe the latest version of the SWISS-MODEL expert system for protein structure modelling. The SWISS-MODEL template library provides annotation of quaternary structure and essential ligands and co-factors to allow for building of complete structural models, including their oligomeric structure. The improved SWISS-MODEL pipeline makes extensive use of model quality estimation for selection of the most suitable templates and provides estimates of the expected accuracy of the resulting models. The accuracy of the models generated by SWISS-MODEL is continuously evaluated by the CAMEO system. The new web site allows users to interactively search for templates, cluster them by sequence similarity, structurally compare alternative templates and select the ones to be used for model building. In cases where multiple alternative template structures are available for a protein of interest, a user-guided template selection step allows building models in different functional states. SWISS-MODEL is available at http://swissmodel.expasy.org/.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (Schwede)
UniBasel Contributors:Schwede, Torsten and Biasini, Marco and Bienert, Stefan and Waterhouse, Andrew and Arnold, Konstantin and Studer, Gabriel and Schmidt, Tobias and Gallo Cassarino, Tiziano and Bordoli, Lorenza
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Oxford University Press
ISSN:0305-1048
e-ISSN:1362-4962
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:10 Oct 2017 08:30
Deposited On:10 Oct 2014 09:19

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