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Contrast-enhanced ultrasound imaging of the vasa vasorum : from early atherosclerosis to the identification of unstable plaques

Staub, Daniel and Schinkel, Arend F. L. and Coll, Blai and Coli, Stefano and van der Steen, Antonius F. W. and Reed, Jess D. and Krueger, Christian and Thomenius, Kai E. and Adam, Dan and Sijbrands, Eric J. and ten Cate, Folkert J. and Feinstein, Steven B.. (2010) Contrast-enhanced ultrasound imaging of the vasa vasorum : from early atherosclerosis to the identification of unstable plaques. Journal of the American College of Cardiology. Cardiovascular imaging, Vol. 3, H. 7. pp. 761-771.

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Official URL: http://edoc.unibas.ch/dok/A6007276

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Abstract

Proliferation of the adventitial vasa vasorum (VV) is inherently linked with early atherosclerotic plaque development and vulnerability. Recently, direct visualization of arterial VV and intraplaque neovascularization has emerged as a new surrogate marker for the early detection of atherosclerotic disease. This clinical review focuses on contrast-enhanced ultrasound (CEUS) as a noninvasive application for identifying and quantifying carotid and coronary artery VV and intraplaque neovascularization. These novel approaches could potentially impact the clinician's ability to identify individuals with premature cardiovascular disease who are at high risk. Once clinically validated, the uses of CEUS may provide a method to noninvasively monitor therapeutic interventions. In the future, the therapeutic use of CEUS may include ultrasound-directed, site-specific therapies using microbubbles as vehicles for drug and gene delivery systems. The combined applications for diagnosis and therapy provide unique opportunities for clinicians to image and direct therapy for individuals with vulnerable lesions.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Angiologie (Jäger)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Angiologie (Jäger)
UniBasel Contributors:Staub, Daniel
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1936-878X
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:12 Sep 2014 08:02
Deposited On:12 Sep 2014 08:02

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