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Crystallization and preliminary X-ray analysis of the coiled-coil domain of dystrophia myotonica kinase

Garcia, P. and Marino, M. and Mayans, O.. (2004) Crystallization and preliminary X-ray analysis of the coiled-coil domain of dystrophia myotonica kinase. Acta Crystallographica. Section D, Biological Crystallography, Vol. 60, Pt. 12,2. pp. 2336-2339.

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Official URL: http://edoc.unibas.ch/dok/A5259371

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Abstract

The coiled-coil domain of dystrophia myotonica protein kinase (DMPK) has been cloned, overexpressed, purified and crystallized. Two crystal forms have been obtained that belong to space groups P3 and P2(1)2(1)2(1) and diffract to 2.4 and 1.6 A resolution, respectively. Experimental phases were obtained by MAD from an SeMet derivative. The location of selenium sites used molecular-replacement phases obtained from search models lacking sequence similarity with the coiled-coil under study. Both crystal forms contain three polypeptide chains in the asymmetric unit.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Mayans)
UniBasel Contributors:Mayans, Olga
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Munksgaard
ISSN:0907-4449
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:18 Jul 2014 09:10
Deposited On:22 Mar 2012 13:22

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