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Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II

Le Moual, Nicole and Carsin, Anne-Elie and Siroux, Valérie and Radon, Katja and Norback, Dan and Torén, Kjell and Olivieri, Mario and Urrutia, Isabel and Cazzoletti, Lucia and Jacquemin, Bénédicte and Benke, Geza and Kromhout, Hans and Mirabelli, Maria C. and Mehta, Amar J. and Schlünssen, Vivi and Sigsgaard, Torben and Blanc, Paul D. and Kogevinas, Manolis and Antó, Josep M. and Zock, Jan-Paul. (2014) Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II. The European respiratory journal, 43 (2). pp. 374-386.

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Official URL: http://edoc.unibas.ch/dok/A6233648

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Abstract

Occupational exposure is a well-recognised modifiable risk factor for asthma, but the relationship between occupational exposure and asthma control has not been studied. We aimed to study this association among working-age adults from the European Community Respiratory Health Survey (ECRHS). Data were available for 7077 participants (mean age 43 years, 45% never-smokers, 5867 without asthma and 1210 with current asthma). Associations between occupational exposure to specific asthmagens and asthma control status (33% with uncontrolled asthma, based on the Global Initiative for Asthma guidelines) were evaluated using logistic and multinomial regressions, adjusted for age, sex and smoking status, with study areas included as a random effect. Statistically significant positive associations were observed between uncontrolled adult-onset asthma and both past 12-month and 10-year exposure to any occupational asthmagens (OR (95% CI) 1.6 (1.0-2.40) and 1.7 (1.2-2.5), respectively); high (1.7 (1.0-2.8) and 1.9 (1.3-2.9), respectively) and low (1.6 (1.0-2.7) and 1.8 (1.2-2.7), respectively) molecular weight agents; and cleaning agents (2.0 (1.1-3.6) and 2.3 (1.4-3.6), respectively), with stronger associations for long-term exposures. These associations were mainly explained by the exacerbation domain of asthma control and no associations were observed between asthmagens and partly controlled asthma. These findings suggest that occupational exposure to asthmagens is associated with uncontrolled adult-onset asthma. Occupational risk factors should be quickly identified to prevent uncontrolled asthma.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Mehta, Amar
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Munksgaard
ISSN:0903-1936
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Language:English
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Last Modified:02 Mar 2018 08:57
Deposited On:15 Aug 2014 07:16

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