Genetic heterogeneity of asthma phenotypes identified by a clustering approach

Siroux, Valérie and González, Juan R. and Bouzigon, Emmanuelle and Curjuric, Ivan and Boudier, Anne and Imboden, Medea and Anto, Josep Maria and Gut, Ivo and Jarvis, Deborah and Lathrop, Mark and Omenaas, Ernst Reidar and Pin, Isabelle and Wjst, Mathias and Demenais, Florence and Probst-Hensch, Nicole and Kogevinas, Manolis and Kauffmann, Francine. (2014) Genetic heterogeneity of asthma phenotypes identified by a clustering approach. The European respiratory journal, 43 (2). pp. 439-452.

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Official URL: http://edoc.unibas.ch/dok/A6233666

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The aim of the study was to identify genetic variants associated with refined asthma phenotypes enabling multiple features of the disease to be taken into account. Latent class analysis (LCA) was applied in 3001 adults ever having asthma recruited in the frame of three epidemiological surveys (the European Community Respiratory Health Survey (ECRHS), the Swiss Study on Air Pollution and Lung Disease in Adults (SAPALDIA) and the Epidemiological Study on the Genetics and Environment of Asthma (EGEA)). 14 personal and phenotypic characteristics, gathered from questionnaires and clinical examination, were used. A genome-wide association study was conducted for each LCA-derived asthma phenotype, compared to subjects without asthma (n=3474). The LCA identified four adult asthma phenotypes, mainly characterised by disease activity, age of asthma onset and atopic status. Associations of genome-wide significance (p>1.25×10(-7)) were observed between "active adult-onset nonallergic asthma" and rs9851461 flanking CD200 (3q13.2) and between "inactive/mild nonallergic asthma" and rs2579931 flanking GRIK2 (6q16.3). Borderline significant results (2.5×10(-7)
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Curjuric, Ivan and Imboden, Medea and Probst Hensch, Nicole
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:03 May 2018 09:37
Deposited On:18 Jul 2014 09:10

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