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Tauopathies with parkinsonism : clinical spectrum, neuropathologic basis, biological markers, and treatment options

Ludolph, A. C. and Kassubek, J. and Landwehrmeyer, B. G. and Mandelkow, E. and Mandelkow, E.-M. and Burn, D. J. and Caparros-Lefebvre, D. and Frey, K. A. and de Yebenes, J. G. and Gasser, T. and Heutink, P. and Höglinger, G. and Jamrozik, Z. and Jellinger, K. A. and Kazantsev, A. and Kretzschmar, H. and Lang, A. E. and Litvan, I. and Lucas, J. J. and McGeer, P. L. and Melquist, S. and Oertel, W. and Otto, M. and Paviour, D. and Reum, T. and Saint-Raymond, A. and Steele, J. C. and Tolnay, M. and Tumani, H. and van Swieten, J. C. and Vanier, M. T. and Vonsattel, J.-P. and Wagner, S. and Wszolek, Z. K.. (2009) Tauopathies with parkinsonism : clinical spectrum, neuropathologic basis, biological markers, and treatment options. European journal of neurology, Vol. 16, H. 3. pp. 297-309.

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Official URL: http://edoc.unibas.ch/dok/A6007654

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Abstract

Tauopathies with parkinsonism represent a spectrum of disease entities unified by the pathologic accumulation of hyperphosphorylated tau protein fragments within the central nervous system. These pathologic characteristics suggest shared pathogenetic pathways and possible molecular targets for disease-modifying therapeutic interventions. Natural history studies, for instance, in progressive supranuclear palsy, frontotemporal dementia with parkinsonism linked to chromosome 17, corticobasal degeneration, and Niemann-Pick disease type C as well as in amyotrophic lateral sclerosis/Parkinson-dementia complex permit clinical characterization of the disease phenotypes and are crucial to the development and validation of biological markers for differential diagnostics and disease monitoring, for example, by use of neuroimaging or proteomic approaches. The wide pathologic and clinical spectrum of the tauopathies with parkinsonism is reviewed in this article, and perspectives on future advances in the understanding of the pathogenesis are given, together with potential therapeutic strategies.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Allgemeine Pathologie (Tolnay)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Allgemeine Pathologie (Tolnay)
UniBasel Contributors:Tolnay, Markus
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Blackwell
ISSN:1351-5101
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:18 Jul 2014 09:10
Deposited On:18 Jul 2014 09:10

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