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The Role of Combination Chemotherapy in the Treatment of Patients with Metastatic Breast Cancer

Huober, Jens and Thürlimann, Beat. (2009) The Role of Combination Chemotherapy in the Treatment of Patients with Metastatic Breast Cancer. Breast Care, 4 (6). pp. 367-372.

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Official URL: http://edoc.unibas.ch/dok/A6008294

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Abstract

Metastatic breast cancer (MBC) is usually not curable, and the primary goals of treatment are thus to control disease and symptoms, maintain quality of life, and prolong life while minimizing toxicity. Chemotherapy is still an important treatment option in MBC, and the decision whether polychemotherapy is preferable to sequential monochemotherapy is under debate. Data are quite consistent in that response rates and time to progression are significantly increased with combination chemotherapy compared to the use of a single agent in MBC patients. Data regarding overall survival with polychemotherapy are not conclusive; however, frequently this approach was associated with increased treatment toxicity and decreased quality of life. Nonetheless, in patients with symptomatic or acute, life-threatening disease, where maximum and quick tumor remission is important, polychemotherapy should be the preferred approach. Furthermore, since some of the newer combination regimens seem to increase toxicity only slightly and substantially prolong time to progression, this approach may also be an option in patients without symptomatic disease.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Onkologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Onkologie
UniBasel Contributors:Thürlimann, Beat
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:S. Karger
ISSN:1661-3791
e-ISSN:1661-3805
Note:Publication type according to Uni Basel Research Database: Journal item
Language:English
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Last Modified:23 Oct 2017 14:10
Deposited On:18 Jul 2014 09:10

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