edoc

Febrile neutropenia and related complications in breast cancer patients receiving pegfilgrastim primary prophylaxis versus current practice neutropaenia management : results from an integrated analysis

von Minckwitz, G. and Schwenkglenks, M. and Skacel, T. and Lyman, G. H. and Pousa, A. Lopez and Bacon, P. and Easton, V. and Aapro, M. S.. (2009) Febrile neutropenia and related complications in breast cancer patients receiving pegfilgrastim primary prophylaxis versus current practice neutropaenia management : results from an integrated analysis. European journal of cancer, Vol. 45, H. 4. pp. 608-617.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6007365

Downloads: Statistics Overview

Abstract

Granulocyte colony-stimulating factors (G-CSFs) reduce febrile neutropaenia (FN) incidence but may be used inconsistently in current practice (CP). This study compared the efficacy of pegfilgrastim primary prophylaxis (PPP) with CP neutropaenia management in breast cancer. Individual patient data (N=2282) from 11 clinical trials and observational studies using chemotherapy regimens with < or =15% FN risk and PPP (6 mg, all cycles) or CP (no G-CSF or any cycle G-CSF/pegfilgrastim) were included in an integrated analysis. Most patients received docetaxel-containing regimens. A generalised linear mixed model was fitted (N=2210). Neutropaenia prophylaxis (PPP versus CP), age and disease stage influenced the incidence of FN. Overall, FN was less frequent with PPP than with CP (odds ratio [OR]: 0.124; 95% confidence interval [CI]: 0.08, 0.194; P>0.0001). Odds for cycle 1 FN, dose reductions < or =15% and FN-related hospitalisation were also significantly lower with PPP. These data support PPP in breast cancer patients receiving chemotherapy with moderately high/high FN risk.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Pharmazeutische Medizin ECPM > Pharmazeutische Medizin (Szucs)
UniBasel Contributors:Schwenkglenks, Matthias
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Pergamon Press
ISSN:0959-8049
Note:Publication type according to Uni Basel Research Database: Journal item
Identification Number:
Last Modified:18 Jul 2014 09:10
Deposited On:18 Jul 2014 09:10

Repository Staff Only: item control page