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[Identification of VHL-associated changes in clear cell renal carcinoma: the application of combined genome and expression analyses]

Boysen, G. and Wollscheid, B. and Bausch-Fluck, D. and Schraml, P. and Moch, H.. (2009) [Identification of VHL-associated changes in clear cell renal carcinoma: the application of combined genome and expression analyses]. Der Pathologe, Vol. 30, Suppl. 2. pp. 188-192.

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Official URL: http://edoc.unibas.ch/dok/A6007500

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Abstract

Sporadic renal cell carcinoma (RCC) represents a heterogeneous tumor, which is traditionally classified into subtypes based on morphological criteria. In recent years high-throughput molecular analyses have been able to identify genomic and proteomic alterations in tumor cells. These markers are the basis for a molecular classification of RCC and bear prognostic value. However, an isolated consideration of genomic and proteomic alterations prevents deeper insights into the complex processes of carcinogenesis. Here we summarize recent studies focussing on this aspect of RCC and present a systems biology concept for the identification of novel tumor markers. These could be applied to improve future diagnosis and therapy of RCC.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB
UniBasel Contributors:Schraml, Peter Hans
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:0172-8113
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:18 Jul 2014 09:10
Deposited On:18 Jul 2014 09:10

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