A guide and guard : the many faces of T-cadherin

Philippova, Maria and Joshi, Manjunath B. and Kyriakakis, Emmanouil and Pfaff, Dennis and Erne, Paul and Resink, Therese J.. (2009) A guide and guard : the many faces of T-cadherin. Cellular signalling, Vol. 21, H. 7. pp. 1035-1044.

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Official URL: http://edoc.unibas.ch/dok/A6007336

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Cadherins are a superfamily of transmembrane proteins that mediate calcium-dependent intercellular adhesion. T-cadherin (T-cad, H-cadherin or cadherin-13) is an atypical member, lacking transmembrane and cytosolic domains and possessing a glycosylphosphatidylinositol moiety that anchors T-cadherin to the plasma membrane. This article reviews current knowledge on the biomolecular characteristics of T-cadherin,its expression and function in different tissues in health and disease and its mechanisms of signal transduction. The structural characteristics of T-cadherin protein predict that it is unlikely to function as a"true" adhesion molecule in vivo. Studies from different fields suggest that it may act rather as a signalling receptor participating in recognition of the environment and regulation of cell motility, proliferation and phenotype. Cellular expression levels of T-cadherin in various tissues frequently correlate (be it negatively or positively) with the proliferative potential of the cells. Loss- and gain-of-function studies demonstrate the ability of T-cadherin to modulate cell motility and growth. Gathering evidence suggests that the "functional predestination" of T-cadherin is in control of tissue architecture through "guiding" navigation of moving structures, segregating functional tissue compartments and "guarding" integrity of functionally connected tissue layers.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Further Research Groups at DBM > Signal Transduction (Resink/Erne)
UniBasel Contributors:Resink, Thérèse J.
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:18 Jul 2014 09:10
Deposited On:18 Jul 2014 09:10

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