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Stopping randomized trials early for benefit and estimation of treatment effects : systematic review and meta-regression analysis

Bassler, Dirk and Briel, Matthias and Montori, Victor M. and Lane, Melanie and Glasziou, Paul and Zhou, Qi and Heels-Ansdell, Diane and Walter, Stephen D. and Guyatt Gordon, H. and Flynn, David N. and Elamin Mohamed, B. and Murad, Mohammad Hassan and Abu Elnour Nisrin, O. and Lampropulos Julianna, F. and Sood, Amit and Mullan, Rebecca J. and Erwin, Patricia J. and Bankhead Clare, R. and Perera, Rafael and Ruiz Culebro, Carolina and You, John J. and Mulla Sohail, M. and Kaur, Jagdeep and Nerenberg Kara, A. and Schünemann, Holger and Cook, Deborah J. and Lutz, Kristina and Ribic, Christine M. and Vale, Noah and Malaga, German and Akl Elie, A. and Ferreira-Gonzalez, Ignacio and Alonso-Coello, Pablo and Urrutia, Gerard and Kunz, Regina and Bucher, Heiner C. and Nordmann, Alain J. and Raatz, Heike and da Silva, Suzana Alves and Tuche, Fabio and Strahm, Brigitte and Djulbegovic, Benjamin and Adhikari Neill, K. J. and Mills, Edward J. and Gwadry-Sridhar, Femida and Kirpalani, Haresh and Soares Heloisa, P. and Karanicolas, Paul J. and Burns, Karen E. A. and Vandvik, Per Olav and Coto-Yglesias, Fernando and Chrispim, Pedro Paulo M. and Ramsay, Tim. (2010) Stopping randomized trials early for benefit and estimation of treatment effects : systematic review and meta-regression analysis. JAMA : the journal of the American Medical Association, Vol. 303, H. 12. pp. 1180-1187.

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Official URL: http://edoc.unibas.ch/dok/A6007577

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Abstract

Theory and simulation suggest that randomized controlled trials (RCTs) stopped early for benefit (truncated RCTs) systematically overestimate treatment effects for the outcome that precipitated early stopping.
Faculties and Departments:03 Faculty of Medicine > Departement Klinische Forschung > Clinical Epidemiology and Biostatistics CEB > Klinische Epidemiologie (Bucher H)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Versicherungsmedizin > Versicherungsmedizin (Kunz)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Versicherungsmedizin > Versicherungsmedizin (Kunz)
UniBasel Contributors:Bucher, Heiner C. and Nordmann, Alain J. and Kunz, Regina and Briel, Matthias
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:American Medical Association
ISSN:0098-7484
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:18 Jul 2014 09:10
Deposited On:18 Jul 2014 09:10

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