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Aplastic anemia : first-line treatment by immunosuppression and sibling marrow transplantation

Passweg, Jakob R. and Marsh, Judith C. W.. (2010) Aplastic anemia : first-line treatment by immunosuppression and sibling marrow transplantation. Hematology : American Society of Hematology education program book, Vol. 2010, no. 1. pp. 36-42.

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Official URL: http://edoc.unibas.ch/dok/A6007691

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Abstract

Newly diagnosed aplastic anemia is a serious condition, with more than 75% (higher in young patients) becoming long-term survivors if diagnosed and treated appropriately. First-line treatment approaches include immunosuppressive treatment using the combination of antithymocyte globulin and cyclosporine A for patients without a sibling donor and HLA identical sibling transplant for patients younger than age 40 with a donor. Best transplant strategies have been defined and include conditioning with cyclophosphamide and antithymocyte globulin, marrow as a stem cell source, and graft-versus-host diease prophylaxis using cyclosporine A and methotrexate. It is against these standard treatment approaches that any therapeutic progress has to be measured.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Hämatologie > Hämatologie (Passweg)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Hämatologie > Hämatologie (Passweg)
UniBasel Contributors:Passweg, Jakob R.
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:American Society of Hematology
Note:Publication type according to Uni Basel Research Database: Journal item
Last Modified:18 Jul 2014 09:09
Deposited On:18 Jul 2014 07:42

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