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Porcine models of coronary atherosclerosis and vulnerable plaque for imaging and interventional research

Granada, Juan F. and Kaluza, Greg L. and Wilensky, Robert L. and Biedermann, Barbara C. and Schwartz, Robert S. and Falk, Erling. (2009) Porcine models of coronary atherosclerosis and vulnerable plaque for imaging and interventional research. EuroIntervention, Vol. 5, H. 1. pp. 140-148.

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Official URL: http://edoc.unibas.ch/dok/A6007677

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Abstract

Animal models facilitate our understanding of human disease by providing a controlled environment permitting testing of mechanisms of disease, diagnostic technologies and therapeutic interventions. The ideal animal model should display coronary lesions resembling those seen in human atherosclerosis. No suitable large animal model of high-risk (vulnerable) plaque exists. Lack of such a model has hampered studies designed to validate imaging technologies and to scrutinise the effects of therapeutic interventions in atherosclerotic arteries. Several porcine models of advanced human-like coronary atherosclerosis exist. In this review some of the most promising porcine models are discussed, focusing on their applicability in the development and validation of coronary imaging technologies and interventional devices. In the evolving era of technological development, the availability and use of such animal models of advanced human-like coronary atherosclerosis and vulnerable plaque will become critically important in the preclinical testing of emerging technologies in interventional cardiology.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Nephrologie > Exp. Transplantationsimmunologie und Nephrologie (Palmer)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Nephrologie > Exp. Transplantationsimmunologie und Nephrologie (Palmer)
UniBasel Contributors:Biedermann, Barbara C.
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Europa Ed.
ISSN:1774-024X
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:20 Jun 2014 07:56
Deposited On:20 Jun 2014 07:56

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