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Acute Fatal Liver Toxicity under Erlotinib

Schacher-Kaufmann, Sabina and Pless, Miklos. (2010) Acute Fatal Liver Toxicity under Erlotinib. Case Reports in Oncology, 3 (2). pp. 182-188.

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Official URL: http://edoc.unibas.ch/dok/A6008217

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Abstract

We describe the case of a never-smoker who received second-line erlotinib as a treatment for his non-small cell lung cancer. Within one month, acute hepatic failure developed as well as a thrombotic-thrombocytopenic microangiopathy, with fatal outcome. In patients with non-small cell lung cancer, hepatic toxicity of erlotinib is a rare but severe complication; so far three fatal cases have been reported. Patients' liver function should be assessed before starting erlotinib and special care is recommended if pretreatment bilirubin is elevated.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Onkologie (Herrmann)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Onkologie (Herrmann)
UniBasel Contributors:Pless, Miklos
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Karger
e-ISSN:1662-6575
Note:Publication type according to Uni Basel Research Database: Journal item
Language:English
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Last Modified:10 Oct 2017 10:44
Deposited On:20 Jun 2014 07:56

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