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Cohort profile: Greifswald Approach to Individualized Medicine (GANI_MED)

Grabe, H. J. and Assel, H. and Bahls, T. and Dörr, M. and Endlich, K. and Endlich, N. and Erdmann, P. and Ewert, R. and Felix, S. and Fiene, B. and Fischer, T. and Flessa, S. and Friedrich, N. and Gardebusch-Bondio, M. and Gesell Salazar, M. and Hammer, E. and Haring, R. and Havemann, C. and Hecker, M. and Hoffmann, W. and Holtfelter, B. and Kacproski, T. and Klein, K. and Kocher, T. and Kock, H. and Krafczyk, J. and Kuhn, J. and Langanke, M. and Lendeckel, U. and Lerch, M. M. and Lieb, W. and Lorbeer, R. and Mayerle, J. and Meissner, K. and Meyer zu Schwabedissen, H. E. and Nauck, M. and Ott, K. and Rathmann, W. and Rettig, R. and Richardt, C. and Saljé, K. and Schminke, U. and Schulz, A. and Schwab, M. and Siegmund, W. and Stracke, S. and Suhre, K. and Ueffing, M. and Ungerer, S. and Völker, U. and Völzke, H. and Wallaschofski, H. and Werner, V. and Zygmunt, M. T. and Kroemer, H. K.. (2014) Cohort profile: Greifswald Approach to Individualized Medicine (GANI_MED). Journal of translational medicine, Vol. 12, H. 1 , 15. p. 15.

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Official URL: http://edoc.unibas.ch/dok/A6263169

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Abstract

BACKGROUND: Individualized Medicine aims at providing optimal treatment for an individual patient at a given time based on his specific genetic and molecular characteristics. This requires excellent clinical stratification of patients as well as the availability of genomic data and biomarkers as prerequisites for the development of novel diagnostic tools and therapeutic strategies. The University Medicine Greifswald, Germany, has launched the "Greifswald Approach to Individualized Medicine" (GANI_MED) project to address major challenges of Individualized Medicine. Herein, we describe the implementation of the scientific and clinical infrastructure that allows future translation of findings relevant to Individualized Medicine into clinical practice.Methods/design: Clinical patient cohorts (N < 5,000) with an emphasis on metabolic and cardiovascular diseases are being established following a standardized protocol for the assessment of medical history, laboratory biomarkers, and the collection of various biosamples for bio-banking purposes. A multi-omics based biomarker assessment including genome-wide genotyping, transcriptome, metabolome, and proteome analyses complements the multi-level approach of GANI_MED. Comparisons with the general background population as characterized by our Study of Health in Pomerania (SHIP) are performed. A central data management structure has been implemented to capture and integrate all relevant clinical data for research purposes. Ethical research projects on informed consent procedures, reporting of incidental findings, and economic evaluations were launched in parallel.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Biopharmazie (Meyer zu Schwabedissen)
UniBasel Contributors:Meyer zu Schwabedissen, H.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:BioMed Central
ISSN:1479-5876
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 May 2015 08:45
Deposited On:20 Jun 2014 07:56

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