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Pegfilgrastim primary prophylaxis vs. current practice neutropenia management in elderly breast cancer patients receiving chemotherapy

Aapro, Matti and Schwenkglenks, Matthias and Lyman, Gary H. and Lopez Pousa, Antonio and Lawrinson, Susan and Skacel, Tomas and Bacon, Pamela and von Minckwitz, Gunter. (2010) Pegfilgrastim primary prophylaxis vs. current practice neutropenia management in elderly breast cancer patients receiving chemotherapy. Critical reviews in oncology, hematology, Vol. 74, H. 3. pp. 203-210.

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Official URL: http://edoc.unibas.ch/dok/A6007287

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Abstract

We investigated the incidences of febrile neutropenia (FN) and related complications in elderly (< or =65 years) breast cancer patients receiving chemotherapy supported by pegfilgrastim primary prophylaxis (PP; n=150) or current practice (CP) neutropenia management (n=104) in a subanalysis of NeuCuP (Neulasta) vs. current practice neutropenia management). Studies involving regimens with moderately high to high (< or =15%) FN risk were identified by literature review, and individual patient data were integrated for analysis. FN incidence was 6% (95% CI: 2, 10%) in the PP group and 24% (95% CI: 16, 32%) in the CP group. In cycle 1, incidences were 3 and 15%, respectively. FN-related hospitalisation incidence was 5% (PP group) and 15% (CP group), while dose reductions (</=15%) occurred in 15 and 29% of patients. Pegfilgrastim provided effective PP in elderly patients, a population who may be vulnerable to chemotherapy-related FN and for whom current practice may not provide adequate protection.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Pharmazeutische Medizin ECPM > Pharmazeutische Medizin (Szucs)
UniBasel Contributors:Schwenkglenks, Matthias
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0737-9587
Note:Publication type according to Uni Basel Research Database: Journal item
Last Modified:20 Jun 2014 07:56
Deposited On:20 Jun 2014 07:56

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