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Contemporary immunotherapy of solid tumors : from tumor-associated antigens to combination treatments

Spagnoli, Giulio C. and Ebrahimi, Marzieh and Iezzi, Giandomenica and Mengus, Chantal and Zajac, Paul. (2010) Contemporary immunotherapy of solid tumors : from tumor-associated antigens to combination treatments. Current opinion in drug discovery & development, Vol. 13, H. 2. pp. 184-192.

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Official URL: http://edoc.unibas.ch/dok/A6007712

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Abstract

The possibility of using the immune system of patients to control tumor outgrowth in a therapeutic setting has always been highly appealing to both clinicians and researchers. However, although cancer cells express tumor-associated antigens that can be targeted by T-cells, clinical trials suggest that the induction of specific immune responses per se may be insufficient to achieve clinical goals. Based on these trial data, in addition to experimental data revealing the complexity of mechanisms controlling immune responsiveness, a reassessment of immunotherapy procedures is underway. As a result, a second generation of antitumor treatments that includes reagents of potential pharmaceutical relevance is being developed. In this review, the most recent literature addressing issues related to immunotherapy for solid tumors is discussed.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Oncology Surgery (Spagnoli)
03 Faculty of Medicine > Bereich Operative Fächer (Klinik) > Querschnittsbereich Forschung
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Operative Fächer (Klinik) > Querschnittsbereich Forschung
UniBasel Contributors:Spagnoli, Giulio C. and Zajac, Paul
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Thomson Scientific
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:04 Sep 2015 14:31
Deposited On:20 Jun 2014 07:56

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