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Drug profile : transdermal rivastigmine patch in the treatment of Alzheimer disease

Emre, Murat and Bernabei, Roberto and Blesa, Rafael and Bullock, Roger and Cunha, Luis and Daniëls, Hugo and Dziadulewicz, Edward and Förstl, Hans and Frölich, Lutz and Gabryelewicz, Tomasz and Levin, Oleg and Lindesay, James and Martínez-Lage, Pablo and Monsch, Andreas and Tsolaki, Magda and van Laar, Teus. (2010) Drug profile : transdermal rivastigmine patch in the treatment of Alzheimer disease. CNS neuroscience & therapeutics, Vol. 16, H. 4. pp. 246-253.

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Official URL: http://edoc.unibas.ch/dok/A6007247

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Abstract

Cholinesterase inhibitors constitute one of the mainstays of treatment of Alzheimer disease (AD). Gastrointestinal side effects, difficulty accessing therapeutic doses and poor patient compliance have been identified as barriers to effective treatment with these substances. The rivastigmine transdermal patch provides continuous delivery of drug through the skin into the bloodstream, avoiding the fluctuations in plasma concentration associated with oral administration. This pharmacokinetic profile is associated with reduced side effects, resulting in easier access to expected target doses. These benefits, along with other practical advantages of the transdermal patch, may contribute to enhanced patient compliance. Here, we present a review of the current literature on rivastigmine patch, and offer advice based on our own collective clinical experience. Rivastigmine patch provides an efficient option for managing patients with AD, to be considered among the first line therapies for the disease.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Geriatrie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Geriatrie
UniBasel Contributors:Monsch, Andreas U
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Wiley-Blackwell
ISSN:1755-5930
Note:Publication type according to Uni Basel Research Database: Journal item
Last Modified:20 Jun 2014 07:55
Deposited On:20 Jun 2014 07:55

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