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Natriuretic peptides in acute coronary syndromes : prognostic value and clinical implications

Farmakis, Dimitrios and Filippatos, Gerasimos and Tubaro, Marco and Peacock, W. Frank and Disomma, Salvatore and Mueller, Christian and Kremastinos, Dimitrios Th and Maisel, Alan S.. (2008) Natriuretic peptides in acute coronary syndromes : prognostic value and clinical implications. Congestive heart failure, Vol. 14, H. 4, Suppl. 1. pp. 25-29.

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Official URL: http://edoc.unibas.ch/dok/A6007581

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Abstract

Levels of natriuretic peptides, including B-type natriuretic peptide and N-terminal prohormone brain natriuretic peptide, are strong independent predictors of prognosis in acute coronary syndrome (ACS). They are associated with short- and long-term mortality and with the risk of new-onset heart failure, above and beyond the conventional risk factors. Myocardial ischemia and ventricular wall stress are triggers for the release of natriuretic peptides, and although the latter are associated with the severity of the underlying coronary artery disease, they fail to predict recurrent nonfatal ACS. In conclusion, natriuretic peptide values may improve risk stratification in ACS when used in addition to troponin levels and other prognostic markers, but more data are needed to define their role in ACS therapy.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Stationäre innere Medizin (Schifferli)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Stationäre innere Medizin (Schifferli)
UniBasel Contributors:Müller, Christian
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Blackwell
ISSN:1527-5299
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:20 Jun 2014 07:55
Deposited On:20 Jun 2014 07:55

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