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State of the art: using natriuretic peptide levels in clinical practice

Maisel, Alan and Mueller, Christian and Adams, Kirkwood and Anker, Stefan D. and Aspromonte, Nadia and Cleland, John G. F. and Cohen-Solal, Alain and Dahlstrom, Ulf and DeMaria, Anthony and Di Somma, Salvatore and Filippatos, Gerasimos S. and Fonarow, Gregg C. and Jourdain, Patrick and Komajda, Michel and Liu, Peter P. and McDonagh, Theresa and McDonald, Kenneth and Mebazaa, Alexandre and Nieminen, Markku S. and Peacock, W. Frank and Tubaro, Marco and Valle, Roberto and Vanderhyden, Marc and Yancy, Clyde W. and Zannad, Faiez and Braunwald, Eugene. (2008) State of the art: using natriuretic peptide levels in clinical practice. European journal of heart failure, Vol. 10, H. 9. pp. 824-839.

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Official URL: http://edoc.unibas.ch/dok/A6007465

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Abstract

Natriuretic peptide (NP) levels (B-type natriuretic peptide (BNP) and N-terminal proBNP) are now widely used in clinical practice and cardiovascular research throughout the world and have been incorporated into most national and international cardiovascular guidelines for heart failure. The role of NP levels in state-of-the-art clinical practice is evolving rapidly. This paper reviews and highlights ten key messages to clinicians: 1) NP levels are quantitative plasma biomarkers of heart failure (HF). 2) NP levels are accurate in the diagnosis of HF. 3) NP levels may help risk stratify emergency department (ED) patients with regard to the need for hospital admission or direct ED discharge. 4) NP levels help improve patient management and reduce total treatment costs in patients with acute dyspnoea. 5) NP levels at the time of admission are powerful predictors of outcome in predicting death and re-hospitalisation in HF patients. 6) NP levels at discharge aid in risk stratification of the HF patient. 7) NP-guided therapy may improve morbidity and/or mortality in chronic HF. 8) The combination of NP levels together with symptoms, signs and weight gain assists in the assessment of clinical decompensation in HF. 9) NP levels can accelerate accurate diagnosis of heart failure presenting in primary care. 10) NP levels may be helpful to screen for asymptomatic left ventricular dysfunction in high-risk patients.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Stationäre innere Medizin (Schifferli)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Stationäre innere Medizin (Schifferli)
UniBasel Contributors:Müller, Christian
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1388-9842
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:20 Jun 2014 07:55
Deposited On:20 Jun 2014 07:55

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