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[Procalcitonin - importance for the diagnosis of bacterial infections]

Christ-Crain, M. and Schuetz, P. and Huber, A. R. and Müller, B.. (2008) [Procalcitonin - importance for the diagnosis of bacterial infections]. Therapeutische Umschau, Vol. 65, H. 9. pp. 559-568.

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Official URL: http://edoc.unibas.ch/dok/A6007502

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Abstract

In contrast to Calcitonin that is primarily synthesized in the thyroid, Procalcitonin is the prohormon that is synthesized in many different tissues of infected organs. In order to be useful for the diagnosis of mild, localized or early infections the assay needs to have a sensitivity that can measure within normal limits (0.02 microg/L). We were able to show that a Procalcitonin algorithm influences the outcome of respiratory infections in terms of minimizing use of antibiotics and duration of antibiotic treatment. High concentrations, especially when seen over time, indicate a high risk of a severe outcome. In this respect, Procalcitonin is superior to other infection markers such as C-reactive Protein (CRP). High Procalcitonin levels can also be seen in non bacterial diseases such as malaria, severe trauma, burns and medullar carcinoma of the thyroid. Together, Procalcitonin has improved the diagnosis of bacterial infections, however should always be used in context with other laboratory markers, clinical exam and medical history.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Allgemeine innere Medizin AG > Argovia Professur für Medizin (Müller)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Allgemeine innere Medizin AG > Argovia Professur für Medizin (Müller)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Endokrinologie / Diabetologie > Endokrinologie (Christ-Crain)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Endokrinologie / Diabetologie > Endokrinologie (Christ-Crain)
UniBasel Contributors:Müller, Beat and Christ-Crain, Mirjam
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Hans Huber
ISSN:0040-5930
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:20 Jun 2014 07:55
Deposited On:20 Jun 2014 07:55

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