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In vitro and in vivo trematode models for chemotherapeutic studies

Keiser, J.. (2010) In vitro and in vivo trematode models for chemotherapeutic studies. Parasitology, 137 (3). pp. 589-603.

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Official URL: http://edoc.unibas.ch/dok/A6007249

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Abstract

Schistosomiasis and food-borne trematodiases are chronic parasitic diseases affecting millions of people mostly in the developing world. Additional drugs should be developed as only few drugs are available for treatment and drug resistance might emerge. In vitro and in vivo whole parasite screens represent essential components of the trematodicidal drug discovery cascade. This review describes the current state-of-the-art of in vitro and in vivo screening systems of the blood fluke Schistosoma mansoni, the liver fluke Fasciola hepatica and the intestinal fluke Echinostoma caproni. Examples of in vitro and in vivo evaluation of compounds for activity are presented. To boost the discovery pipeline for these diseases there is a need to develop validated, robust high-throughput in vitro systems with simple readouts.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Klinische Pharmakologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Klinische Pharmakologie
UniBasel Contributors:Keiser, Jennifer
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Cambridge University Press
ISSN:0031-1820
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:07 Apr 2017 09:23
Deposited On:20 Jun 2014 07:55

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