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Vascular endothelium as "novel" target of graft-versus-host disease

Tichelli, A. and Gratwohl, A.. (2008) Vascular endothelium as "novel" target of graft-versus-host disease. Best practice & research. Clinical haematology, Vol. 21, H. 2. pp. 139-148.

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Official URL: http://edoc.unibas.ch/dok/A6007228

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Abstract

There is increasing evidence of the existence of an endothelial form of graft-versus-host disease (GvHD). The early endothelial injury syndromes - transplant-associated microangiopathy (TAM), veno-occlusive disease (VOD) of the liver, diffuse alveolar hemorrhage, engraftment syndrome, and capillary leak syndrome - all share common features with acute GvHD. They are more likely to occur after allogeneic hematopoietic stem-cell transplantation (HCT), in unrelated transplantation, or with non-T-cell-depleted grafts. In addition, acute GvHD is a risk factor for all these endothelial syndromes. Chronic GvHD leads to a rarefaction of microvessels caused by the infiltration of alloreactive cytotoxic T lymphocytes. Furthermore, late cardiovascular accidents are more likely to occur in patients treated with allogeneic than autologous HCT, suggesting that an immunological mechanism is involved in the development of atherosclerosis. Finally, biomarkers of endothelial injury show a close relationship with GvHD. These data support the notion that early endothelial damage syndromes, atherosclerosis, and vascular endothelial GvHD share a common denominator in patients treated with allogeneic HCT.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Ehemalige Einheiten Querschnittsfächer (Klinik) > Diagnostische Hämatologie (Tichelli)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Ehemalige Einheiten Querschnittsfächer (Klinik) > Diagnostische Hämatologie (Tichelli)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Hämatologie (Gratwohl)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Hämatologie (Gratwohl)
UniBasel Contributors:Tichelli, André and Gratwohl, Alois A.
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Baillière Tindall
ISSN:1521-6926
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:20 Jun 2014 07:55
Deposited On:20 Jun 2014 07:55

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