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How T cells get grip on lipid antigens

De Libero, G. and Mori, L.. (2008) How T cells get grip on lipid antigens. Current opinion in immunology, Vol. 20, H. 1. pp. 96-104.

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Official URL: http://edoc.unibas.ch/dok/A6007388

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Abstract

Lipid antigens are presented to T cells as complexes formed with CD1 family members. The hydrophobic nature of lipids influences how they remain in biological fluids, are distributed within cells, and are handled to become immunogenic. Continuously expanding knowledge shows how lipids are internalized by APC, traffic through the endocytic system, are processed to generate immunogenic molecules, and are loaded on CD1 proteins. The molecular bases of how lipids interact with CD1 and TCR are being defined. A breakthrough in the field has been the discovery that exogenous and endogenous lipids stimulate T cells which mount adaptive and innate-like responses. Disclosure of molecular protagonists and mechanisms of both responses has great promise for development of novel lipid-based vaccines and immunotherapies.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Experimental Immunology (De Libero)
UniBasel Contributors:De Libero, Gennaro
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Current Biology
ISSN:0952-7915
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:23 May 2014 08:34
Deposited On:23 May 2014 08:34

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