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Breast cancer risk in postmenopausal women using testosterone in combination with hormone replacement therapy

Bitzer, J. and Kenemans, P. and Mueck, A. O. and FSDeducation, Group. (2008) Breast cancer risk in postmenopausal women using testosterone in combination with hormone replacement therapy. Maturitas, Vol. 59. pp. 209-218.

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Official URL: http://edoc.unibas.ch/dok/A6007262

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Abstract

OBJECTIVES: Testosterone supplementation can be considered as a treatment option for surgically postmenopausal women with a distressful low sexual desire disorder, while on oestrogen therapy with or without progestagens. The purpose of this study is to review the available clinical data on the impact of exogenous testosterone containing postmenopausal hormone therapy on breast cancer risk. METHODS: A literature search was done in MEDLINE (1969-July 2007) and in addition in EMBASE and Biosis (1990-July 2007) for original reports in English and French. Case reports and studies without a control group were excluded. RESULTS: No prospective randomized clinical trials were found. The five studies found (two case-control studies, two cohort studies and one retrospective observational study) showed inconsistent results. All studies had severe methodological limitations. Formulations and dosages used could be considered suboptimal. CONCLUSION: At present, there are no valid randomized or observational clinical studies that provide evidence that the addition of testosterone to conventional postmenopausal hormone therapy influences breast cancer risk.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Ehemalige Einheiten Spezialfächer (Klinik) > Geburtshilfliche und Gynäkologische Psychosomatik (Bitzer)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Ehemalige Einheiten Spezialfächer (Klinik) > Geburtshilfliche und Gynäkologische Psychosomatik (Bitzer)
UniBasel Contributors:Bitzer, Johannes
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
ISSN:0378-5122
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:23 May 2014 08:34
Deposited On:23 May 2014 08:34

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