edoc

Donor characteristics affecting graft failure, graft-versus-host disease, and survival after unrelated donor transplantation with reduced-intensity conditioning for hematologic malignancies

Passweg, Jakob R. and Zhang, Mei-Jie and Rocha, Vanderson and Kan, Fangyu and Champlin, Richard E. and Isola, Luis M. and Gee, Adrian P. and Gibson, John and Laughlin, Mary J. and Lazarus, Hillard M. and Loren, Alison and Marks, David I. and Gratwohl, Alois and Eapen, Mary. (2011) Donor characteristics affecting graft failure, graft-versus-host disease, and survival after unrelated donor transplantation with reduced-intensity conditioning for hematologic malignancies. Biology of blood and marrow transplantation, Vol. 17, H. 12. pp. 1869-1873.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6005932

Downloads: Statistics Overview

Abstract

We examined the effect of donor characteristics on graft failure (>5% donor chimerism within 3 months after transplantation), acute and chronic graft-versus-host disease (aGVHD, cGVHD), and survival after unrelated donor reduced-intensity conditioning (RIC) transplantation in 709 patients with hematologic malignancies. Donor-recipient pairs were HLA typed at HLA-A, -B, -C, and -DRB1 (allele-level). A total of 501 patients were <95% donor chimerism, 145 patients were 5% to 95%, and 63 patients were >5%. The only donor characteristic associated with transplantation outcome was donor-recipient HLA matching. One- or 2-loci mismatched transplants led to higher grade 2-4 (relative risk [RR] = 1.27, P = .035) and grade 3-4 (RR = 1.85, P > .001) aGVHD and 2-loci mismatched transplants higher mortality (RR = 2.22, P > .001). Graft failure was higher after transplantation of bone marrow (RR = 2.33, P = .002). Donor age, parity, and donor sex match were not associated with transplantation outcome. Donor-recipient HLA matching is the only donor characteristic predictive for survival after RIC regimens for hematologic malignancies.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Hämatologie > Hämatologie (Passweg)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Hämatologie > Hämatologie (Passweg)
UniBasel Contributors:Passweg, Jakob R.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1083-8791
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:23 May 2014 08:34
Deposited On:23 May 2014 08:34

Repository Staff Only: item control page