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Heterogeneity of the Yersinia YopM protein

Boland, A. and Havaux, S. and Cornelis, G. R.. (1998) Heterogeneity of the Yersinia YopM protein. Microbial pathogenesis, Vol. 25, H. 6. pp. 343-348.

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Official URL: http://edoc.unibas.ch/dok/A5259191

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Abstract

Virulent Yersinia species (Y. pestis, Y. pseudotuberculosis and Y. enterocolitica) possess a 70 kb virulence plasmid that encodes the Yop virulon. This virulence system allows extracellular bacteria adhering at the surface of eukaryotic cells to secrete and inject bacterial effector proteins, called Yops, into the cytosol of these cells in order to disarm them. These secreted Yop proteins are remarkably conserved among the different species. A Y. enterocolitica O:8 strain was found to secrete a protein antigenically related to YopM but significantly larger. Sequencing of the corresponding gene showed that the protein was a YopM variant with three repeats of one domain. Comparison of the yopM gene of various Yersinia strains by PCR amplification, as well as analysis of the secreted Yop proteins by SDS-PAGE and Western blotting revealed that, unlike the other Yops, the YopM protein shows some heterogeneity.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Molecular Microbiology (Cornelis)
UniBasel Contributors:Cornelis, Guy R.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Academic Press
ISSN:0882-4010
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:20
Deposited On:22 Mar 2012 13:22

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