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Viral impact on long-term kidney graft function

Helanterä, Ilkka and Egli, Adrian and Koskinen, Petri and Lautenschlager, Irmeli and Hirsch, Hans H.. (2010) Viral impact on long-term kidney graft function. Infectious disease clinics of North America, Vol. 24, H. 2. pp. 339-371.

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Official URL: http://edoc.unibas.ch/dok/A6007718

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Abstract

Acute rejection episodes are an important risk factor for the functional deterioration of solid-organ transplants. With more intense immunosuppressive protocols, the rate of acute rejection episodes has significantly declined in the last decade, but long-term graft function and graft survival are challenged by increasing viral complications. In this article, recent data on the role of adenovirus, polyomavirus BK and JC, cytomegalovirus, human herpesvirus-6 and -7, and parvovirus B19 on the long-term outcome of kidney transplantation are reviewed. An update on the pathophysiology of smoldering viral replication, associated inflammatory damage, and the presumed indirect viral effects is provided, and the implications for diagnostic tests and antiviral intervention are discussed.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Transplantation Virology (Hirsch)
UniBasel Contributors:Hirsch, Hans H.
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
ISSN:0891-5520
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:23 May 2014 08:33
Deposited On:23 May 2014 08:33

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