The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background : evidence from a large collaborative study totaling 4,963 subjects

Rizzi, Thais S. and Arias-Vasquez, Alejandro and Rommelse, Nanda and Kuntsi, Jonna and Anney, Richard and Asherson, Philip and Buitelaar, Jan and Banaschewski, Tobias and Ebstein, Richard and Ruano, Dina and Van der Sluis, Sophie and Markunas, Christina A. and Garrett, Melanie E. and Ashley-Koch, Allison E. and Kollins, Scott H. and Anastopoulos, Arthur D. and Hansell, Narelle K. and Wright, Margaret J. and Montgomery, Grant W. and Martin, Nicholas G. and Harris, Sarah E. and Davies, Gail and Tenesa, Albert and Porteous, David J. and Starr, John M. and Deary, Ian J. and St Pourcain, Beate and Davey Smith, George and Timpson, Nicholas J. and Evans, David M. and Gill, Michael and Miranda, Ana and Mulas, Fernando and Oades, Robert D. and Roeyers, Herbert and Rothenberger, Aribert and Sergeant, Joseph and Sonuga-Barke, Edmund and Steinhausen, Hans Christoph and Taylor, Eric and Faraone, Stephen V. and Franke, Barbara and Posthuma, Danielle. (2011) The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background : evidence from a large collaborative study totaling 4,963 subjects. American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol. 156, H. 2. pp. 145-157.

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Official URL: http://edoc.unibas.ch/dok/A6243545

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Intelligence is a highly heritable trait for which it has proven difficult to identify the actual genes. In the past decade, five whole-genome linkage scans have suggested genomic regions important to human intelligence; however, so far none of the responsible genes or variants in those regions have been identified. Apart from these regions, a handful of candidate genes have been identified, although most of these are in need of replication. The recent growth in publicly available data sets that contain both whole genome association data and a wealth of phenotypic data, serves as an excellent resource for fine mapping and candidate gene replication. We used the publicly available data of 947 families participating in the International Multi-Centre ADHD Genetics (IMAGE) study to conduct an in silico fine mapping study of previously associated genomic locations, and to attempt replication of previously reported candidate genes for intelligence. Although this sample was ascertained for attention deficit/hyperactivity disorder (ADHD), intelligence quotient (IQ) scores were distributed normally. We tested 667 single nucleotide polymorphisms (SNPs) within 15 previously reported candidate genes for intelligence and 29451 SNPs in five genomic loci previously identified through whole genome linkage and association analyses. Significant SNPs were tested in four independent samples (4,357 subjects), one ascertained for ADHD, and three population-based samples. Associations between intelligence and SNPs in the ATXN1 and TRIM31 genes and in three genomic locations showed replicated association, but only in the samples ascertained for ADHD, suggesting that these genetic variants become particularly relevant to IQ on the background of a psychiatric disorder.
Faculties and Departments:07 Faculty of Psychology
07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Clinical Child and Adolescent Psychology (Schneider)
UniBasel Contributors:Steinhausen, Hans-Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:25 Apr 2014 08:01
Deposited On:25 Apr 2014 08:01

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