edoc

Cell-specific integration of artificial organelles based on functionalized polymer vesicles

Ben-Haim, N. and Broz, P. and Marsch, S. and Meier, W. and Hunziker, P.. (2008) Cell-specific integration of artificial organelles based on functionalized polymer vesicles. Nano Letters, 8 (5). pp. 1368-1373.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6007160

Downloads: Statistics Overview

Abstract

Cell organelles are subcellular structures characterized by specific functionalities. They often consist of membrane-delineated microcompartments with a unique set of enzymes. Here we report the design of synthetic organelles based on nanometer-sized polymer vesicles, show their introduction into cells in a target-specific fashion, document their intact biochemical functionality in the cellular environment, and study their intracellular trafficking. This novel paradigm of introducing polymer-based artificial organelles to specific target cells for expansion of their biochemical capabilities appears suited for biomedical applications such as enzyme replacement in genetic diseases or, more generically, to add a desired biochemical function to a cell.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Intensivmedizin > Intensivmedizin (Marsch)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Intensivmedizin > Intensivmedizin (Marsch)
UniBasel Contributors:Marsch, Stephan and Hunziker, Patrick R.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
ISSN:1530-6984
e-ISSN:1530-6992
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:11 Mar 2020 11:42
Deposited On:25 Apr 2014 08:01

Repository Staff Only: item control page