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Cell-specific integration of artificial organelles based on functionalized polymer vesicles

Ben-Haim, N. and Broz, P. and Marsch, S. and Meier, W. and Hunziker, P.. (2008) Cell-specific integration of artificial organelles based on functionalized polymer vesicles. Nano Letters, Vol. 8, H. 5. pp. 1368-1373.

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Official URL: http://edoc.unibas.ch/dok/A6007160

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Abstract

Cell organelles are subcellular structures characterized by specific functionalities. They often consist of membrane-delineated microcompartments with a unique set of enzymes. Here we report the design of synthetic organelles based on nanometer-sized polymer vesicles, show their introduction into cells in a target-specific fashion, document their intact biochemical functionality in the cellular environment, and study their intracellular trafficking. This novel paradigm of introducing polymer-based artificial organelles to specific target cells for expansion of their biochemical capabilities appears suited for biomedical applications such as enzyme replacement in genetic diseases or, more generically, to add a desired biochemical function to a cell.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Intensivmedizin > Intensivmedizin (Marsch)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Intensivmedizin > Intensivmedizin (Marsch)
UniBasel Contributors:Marsch, Stephan and Hunziker, Patrick R.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Chemical Society
ISSN:1530-6984
e-ISSN:1530-6992
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:13 Oct 2017 07:34
Deposited On:25 Apr 2014 08:01

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