Clinical value of optical coherence tomography in laryngology

Kraft, Marcel and Glanz, Hiltrud and von Gerlach, Susanne and Wisweh, Henning and Lubatschowski, Holger and Arens, Christoph. (2008) Clinical value of optical coherence tomography in laryngology. Head & neck, Vol. 30, H. 12. pp. 1628-1635.

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Official URL: http://edoc.unibas.ch/dok/A6006369

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BACKGROUND: Optical coherence tomography (OCT) is a new, noninvasive imaging technology for the evaluation of superficial lesions. The objective of this study is to evaluate microlaryngoscopy in combination with OCT compared with microlaryngoscopy alone (ie, without OCT) in supplying a specific diagnosis, predicting invasive tumor growth and epithelial dysplasia in the larynx. METHODS: This was a prospective study including 217 laryngeal lesions in a total of 193 patients undergoing surgery. Intraoperative suspicion diagnosis gained by microlaryngoscopy with and without OCT was compared with conventional histopathology after excisional biopsy. RESULTS: Microlaryngoscopy with OCT supplied a specific diagnosis in 89% of cases, but in only 80% of cases with microlaryngoscopy alone. In particular, our results in malignant and benign pathologies were correct in 93% each, and the exact grade of dysplasia could be predicted in 71% of precancerous lesions. Microlaryngoscopy with OCT presented a higher sensitivity than microlaryngoscopy alone in predicting invasive tumor growth (93% vs 87%) and epithelial dysplasia (78% vs 66%), but the specificity and accuracy were comparable in both methods. CONCLUSIONS: OCT is a simple, rapid, and reliable aid in the diagnostic investigation and intraoperative monitoring of laryngeal disease.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Ehemalige Einheiten Spezialfächer (Klinik) > Oto-Rhino-Laryngologie AG (Podvinec)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Ehemalige Einheiten Spezialfächer (Klinik) > Oto-Rhino-Laryngologie AG (Podvinec)
UniBasel Contributors:Kraft, Marcel Thomas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:John Wiley
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:25 Apr 2014 08:01
Deposited On:25 Apr 2014 08:01

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