Schwann cell strip for peripheral nerve repair

Kalbermatten, D. F. and Erba, P. and Mahay, D. and Wiberg, M. and Pierer, G. and Terenghi, G.. (2008) Schwann cell strip for peripheral nerve repair. The journal of hand surgery. E, European volume, Vol. 33, H. 5. pp. 587-594.

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Official URL: http://edoc.unibas.ch/dok/A6003175

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Many strategies have been investigated to provide an ideal substitute to treat a nerve gap injury. Initially, silicone conduits were used and more recently conduits fabricated from natural materials such as poly-3-hydroxybutyrate (PHB) showed good results but still have their limitations. Surgically, a new concept optimising harvested autologous nerve graft has been introduced as the single fascicle method. It has been shown that a single fascicle repair of nerve grafting is successful. We investigated a new approach using a PHB strip seeded with Schwann cells to mimic a small nerve fascicle. Schwann cells were attached to the PHB strip using diluted fibrin glue and used to bridge a 10-mm sciatic nerve gap in rats. Comparison was made with a group using conventional PHB conduit tubes filled with Schwann cells and fibrin glue. After 2 weeks, the nerve samples were harvested and investigated for axonal and Schwann cell markers. PGP9.5 immunohistochemistry showed a superior nerve regeneration distance in the PHB strip group versus the PHB tube group (< 10 mm, crossed versus 3.17+/- 0.32 mm respectively, P>0.05) as well as superior Schwann cell intrusion (S100 staining) from proximal (< 10 mm, crossed versus 3.40+/- 0.36 mm, P>0.01) and distal (< 10 mm, crossed versus 2.91+/- 0.31 mm, P>0.001) ends. These findings suggest a significant advantage of a strip in rapidly connecting a nerve gap lesion and imply that single fascicle nerve grafting is advantageous for nerve repair in rats.
Faculties and Departments:03 Faculty of Medicine > Bereich Operative Fächer (Klinik) > Bewegungsapparat und Integument
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Operative Fächer (Klinik) > Bewegungsapparat und Integument
UniBasel Contributors:Kalbermatten, Daniel F.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Churchill Livingstone
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:25 Apr 2014 08:01
Deposited On:25 Apr 2014 08:01

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