edoc

Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

Jaeger, E. and Webb, E. and Howarth, K. and Carvajal-Carmona, L. and Rowan, A. and Broderick, P. and Walther, A. and Spain, S. and Pittman, A. and Kemp, Z. and Sullivan, K. and Heinimann, K. and Lubbe, S. and Domingo, E. and Barclay, E. and Martin, L. and Gorman, M. and Chandler, I. and Vijayakrishnan, J. and Wood, W. and Papaemmanuil, E. and Penegar, S. and Qureshi, M. and Corgi, Consortium and Farrington, S. and Tenesa, A. and Cazier, J. B. and Kerr, D. and Gray, R. and Peto, J. and Dunlop, M. and Campbell, H. and Thomas, H. and Houlston, R. and Tomlinson, I.. (2008) Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. Nature genetics, Vol. 40, H. 1. pp. 26-28.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6005505

Downloads: Statistics Overview

Abstract

We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)).
Faculties and Departments:03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Medizinische Genetik (Miny)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Medizinische Genetik (Miny)
UniBasel Contributors:Heinimann, Karl
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publ.
ISSN:1061-4036
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:25 Apr 2014 08:00
Deposited On:25 Apr 2014 08:00

Repository Staff Only: item control page