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Molecular imaging of reduced renal uptake of radiolabelled [DOTA0,Tyr3]octreotate by the combination of lysine and Gelofusine in rats.

Rolleman, E. J. and Bernard, B. F. and Breeman, W. A. P. and Forrer, F. and de Blois, E. and Hoppin, J. and Gotthardt, M. and Boerman, O. C. and Krenning, E. P. and de Jong, M.. (2008) Molecular imaging of reduced renal uptake of radiolabelled [DOTA0,Tyr3]octreotate by the combination of lysine and Gelofusine in rats. Nuklearmedizin, Vol. 47, H. 3. pp. 110-115.

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Official URL: http://edoc.unibas.ch/dok/A6005453

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Abstract

In peptide receptor radionuclide therapy (PRRT) using radiolabelled somatostatin analogues, kidney uptake of radiolabelled compound is the major dose-limiting factor. We studied the effects of Gelofusine (20 mg) and lysine (100 mg) and the combination of both after injection of therapeutic doses of radiolabelled [DOTA0,Tyr3]octreotate (60 MBq 111In or 555 MBq 177Lu labelled to 15 microg peptide) in male Lewis rats.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Radiologie USB > Nuklearmedizin (Wild)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Radiologie USB > Nuklearmedizin (Wild)
UniBasel Contributors:Forrer, Flavio
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Schattauer
ISSN:0029-5566
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:25 Apr 2014 08:00
Deposited On:25 Apr 2014 08:00

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