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Subthalamic nucleus stimulation and levodopa-resistant postural instability in Parkinson's disease

Visser, J. E. and Allum, J. H. and Carpenter, M. G. and Esselink, R. A. and Speelman, J. D. and Borm, G. F. and Bloem, B. R.. (2008) Subthalamic nucleus stimulation and levodopa-resistant postural instability in Parkinson's disease. Journal of neurology, Vol. 255, H. 2. pp. 205-210.

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Official URL: http://edoc.unibas.ch/dok/A6005498

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Abstract

We examined the effect of bilateral subthalamic nucleus stimulation on levodopa-resistant balance impairment in 14 patients with Parkinson's disease and 18 matched controls. Instability was quantitatively assessed using standardized multidirectional dynamic posturography. Patients were tested after taking a suprathreshold dose of levodopa, both with stimulators turned on and off. Patients with stimulators turned off were more unstable than controls following backward directed perturbations. Overall, patients' instability did not improve with STN stimulation, and considerable inter-individual variability was noted. Of note, marked levodopa- resistant axial motor symptoms before surgery correlated with an adverse treatment effect. We conclude that STN stimulation does not alleviate levodopa-resistant postural instability in Parkinson's disease.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialf├Ącher (Klinik) > Otorhinolaryngologie > Experimentelle Neurootologie und Audiologie (Allum)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialf├Ącher (Klinik) > Otorhinolaryngologie > Experimentelle Neurootologie und Audiologie (Allum)
UniBasel Contributors:Allum, John H.J.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:0340-5354
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Mar 2014 13:13
Deposited On:27 Mar 2014 13:13

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