Lobar Dementia due to Extreme Widening of Virchow-Robin Spaces in One Hemisphere

Buerge, Christine and Steiger, Gregor and Kneifel, Stefan and Wetzel, Stephan and Wollmer, M. Axel and Probst, Alphonse and Baumann, Thomas P.. (2011) Lobar Dementia due to Extreme Widening of Virchow-Robin Spaces in One Hemisphere. Case Reports in Neurology, 3 (2). pp. 136-140.

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Official URL: http://edoc.unibas.ch/dok/A6003325

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Widened perivascular spaces known as Virchow-Robin spaces (VRS) are often seen on MRI and are usually incidental findings. It is unclear if enlarged VRS can be associated with neurological deficits. In this report, we describe a case of lobar dementia associated with unusual VRS widening in one cerebral hemisphere. A 77-year-old woman, seen at a memory clinic, presented with progressive cognitive decline, left hemianopsia, and mild pyramidal signs on the left side. On MRI, unusually wide VRS were visible, predominantly in the right centrum semiovale and the right temporo-occipital white matter. The clinical syndrome was consistent with the extent and location of the abnormally dilated VRS. The high MR signal in white matter bridges between the VRS suggested parenchymal damage, possibly representing gliotic white matter. No evidence for another etiology was found on cerebral MRI and rCBF SPECT. As a conclusion, enlarged VRS in one cerebral hemisphere may be associated with cognitive change and neurological deficits.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Radiologie USB
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Radiologie USB
UniBasel Contributors:Wetzel, Stephan G.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Oct 2017 10:35
Deposited On:27 Mar 2014 13:13

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