Gamma and alpha motor neurons distinguished by expression of transcription factor Err3

Friese, A. and Kaltschmidt, J. A. and Ladle, D. R. and Sigrist, M. and Jessell, T. M. and Arber, S.. (2009) Gamma and alpha motor neurons distinguished by expression of transcription factor Err3. Proceedings of the National Academy of Sciences of the United States of America, 106 (32). pp. 13588-13593.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A5259063

Downloads: Statistics Overview


Spinal motor neurons are specified to innervate different muscle targets through combinatorial programs of transcription factor expression. Whether transcriptional programs also establish finer aspects of motor neuron subtype identity, notably the prominent functional distinction between alpha and gamma motor neurons, remains unclear. In this study, we identify DNA binding proteins with complementary expression profiles in alpha and gamma motor neurons, providing evidence for molecular distinctions in these two motor neuron subtypes. The transcription factor Err3 is expressed at high levels in gamma but not alpha motor neurons, whereas the neuronal DNA binding protein NeuN marks alpha but not gamma motor neurons. Signals from muscle spindles are needed to support the differentiation of Err3(on)/NeuN(off) presumptive gamma motor neurons, whereas direct proprioceptive sensory input to a motor neuron pool is apparently dispensable. Together, these findings provide evidence that transcriptional programs define functionally distinct motor neuron subpopulations, even within anatomically defined motor pools.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Arber)
Item Type:Article, refereed
Publisher:National Academy of Sciences
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:29 Aug 2019 13:41
Deposited On:22 Mar 2012 13:21

Repository Staff Only: item control page