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Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component

Visco, Carlo and Hoeller, Sylvia and Malik, Jeffrey T. and Xu-Monette, Zijun Y. and Wiggins, Michele L. and Liu, Jessica and Sanger, Warren G. and Liu, Zhongfeng and Chang, Julie and Ranheim, Erik A. and Gradowski, Joel F. and Serrano, Sergio and Wang, Huan-You and Liu, Qingquan and Dave, Sandeep and Olsen, Brian and Gascoyne, Randy D. and Campo, Elias and Swerdlow, Steven H. and Chan, Wing C. and Tzankov, Alexander and Young, Ken H.. (2011) Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component. American journal of surgical pathology, Vol. 35, H. 2. pp. 177-189.

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Official URL: http://edoc.unibas.ch/dok/A6006003

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Abstract

The normal counterparts of mantle cell lymphoma (MCL) are naive, quiescent B cells that have not been processed through the germinal center (GC). For this reason, although lymphomas arising from GC or post-GC B cells often exhibit plasmacytic differentiation, MCL rarely presents with plasmacytic features. Seven cases of MCL with a monotypic plasma cell (PC) population were collected from 6 centers and were studied by immunohistochemistry, fluorescence immunophenotyping and interphase cytogenetics as a tool for the investigation of neoplasms analysis, capillary gel electrophoresis, and restriction fragment length polymorphism of immunoglobulin heavy chain analysis of microdissections of each of the MCL and PC populations to assess their clonal relationship. The clinical presentation was rather unusual compared with typical MCL, with 2 cases arising from the extranodal soft tissues of the head. All MCL cases were morphologically and immunohistochemically typical, bearing the t(11;14)(q13;q32). In all cases, the PC population was clonal. In 5 of the 7 cases, the MCL and PC clones showed identical restriction fragments, indicating a common clonal origin of the neoplastic population. The 2 cases with clonal diversity denoted the coexistence of 2 different tumors in a composite lymphoma/PC neoplasm. Our findings suggest that MCL can present with a PC component that is often clonally related to the lymphoma, representing a rare but unique biological variant of this tumor.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Histopathologie (Dirnhofer)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Histopathologie (Dirnhofer)
UniBasel Contributors:Tzankov, Alexandar
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Masson
ISSN:0147-5185
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:27 Mar 2014 13:13
Deposited On:27 Mar 2014 13:13

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