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mTORC1: Turning Off Is Just as Important as Turning On

Benjamin, D. and Hall, M. N.. (2014) mTORC1: Turning Off Is Just as Important as Turning On. Cell, 156 (4). pp. 627-628.

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Official URL: http://edoc.unibas.ch/dok/A6233681

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Abstract

mTORC1 is activated primarily on the lysosome. Menon et al. and Demetriades et al. show that mTORC1 deactivation on the lysosome is determined by recruitment of its negative regulator, the tumor suppressor complex TSC1-TSC2. These reports highlight the importance of subcellular localization in the regulation of mTORC1.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Cell Press
ISSN:0092-8674
e-ISSN:1097-4172
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:09 Nov 2017 08:03
Deposited On:27 Mar 2014 13:13

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