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Enantioselective total synthesis of virosaine A and bubbialidine

Miyatake-Ondozabal, Hideki and Bannwart, Linda M. and Gademann, Karl. (2013) Enantioselective total synthesis of virosaine A and bubbialidine. Chemical Communications, 49 (19). pp. 1921-1923.

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Abstract

The first enantioselective total syntheses of virosaine A and bubbialidine are described. Key transformations include the formation of a tetracyclic intermediate via an intramolecular aza-Michael addition, generation of a N-hydroxy-pyrrolidine through a Cope elimination and an intramolecular [1,3]-dipolar cycloaddition to generate a complex 7-oxa-1-azabicyclo[3.2.1]octane ring system.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Organische Chemie (Gademann)
UniBasel Contributors:Gademann, Karl
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
ISSN:0022-4936
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:28 Nov 2016 15:21
Deposited On:27 Feb 2014 15:45

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