edoc

Intratumoral plasmacytoid dendritic cells associate with increased survival in patients with follicular lymphoma

Butsch, R. and Lukas Waelti S., and Schaerer, S. and Braun, J. and Korol, D. and Probst-Hensch N., and Moch, H. and Kurrer, M.. (2011) Intratumoral plasmacytoid dendritic cells associate with increased survival in patients with follicular lymphoma. Leukemia & lymphoma, Vol. 52, H. 7. pp. 1230-1238.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6002253

Downloads: Statistics Overview

Abstract

Gene array studies on follicular lymphoma (FL) have associated non-malignant tumor-infiltrating immune cells with patient survival. We examined the role of such cells detectable by immunohistochemistry in a tissue microarray, focusing on plasmacytoid dendritic cells (pDCs). These cells physiologically produce interferon-alpha, which has been used in the therapy of FL. High numbers of pDCs are associated with increased survival, and so are high numbers of CD3+ T cells. The regular distribution of pDCs within T cell areas is reflected by a weak but significant correlation between pDCs and T cells. However, in multivariate Cox models, CD123 proved to be an independent prognostic factor. These findings support the hypothesis of an association of pDCs with better prognosis by producing interferon. Furthermore, due to a linear relationship between pDCs and survival shown by means of Kaplan-Meier plots, immunohistochemical staining of CD123 could serve as a prognostic tool for patients with FL
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Exposome Science (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Exposome Science (Probst-Hensch)
UniBasel Contributors:Probst Hensch, Nicole
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Harwood Academic Publishers
ISSN:1042-8194
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:27 Feb 2014 15:45
Deposited On:27 Feb 2014 15:45

Repository Staff Only: item control page