edoc

Evaluation of a summary score of cognitive performance for use in trials in perioperative and critical care

Burkhart, Christoph S. and Birkner-Binder, Dagmar and Gagneux, Alexa and Berres, Manfred and Strebel, Stephan P. and Monsch, Andreas U. and Steiner, Luzius A.. (2011) Evaluation of a summary score of cognitive performance for use in trials in perioperative and critical care. Dementia and Geriatric Cognitive Disorders, 31 (6). pp. 451-459.

[img]
Preview
PDF - Published Version
522Kb

Official URL: http://edoc.unibas.ch/dok/A6004615

Downloads: Statistics Overview

Abstract

Background/Aims: Cognitive dysfunction after medical treatment is increasingly being recognized. Studies on this topic require repeated cognitive testing within a short time. However, with repeated testing, practice effects must be expected. We quantified practice effects in a demographically corrected summary score of a neuropsychological test battery repeatedly administered to healthy elderly volunteers. Methods: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychological Assessment Battery (for which a demographically corrected summary score was developed), phonemic fluency tests, and trail-making tests were administered in healthy volunteers aged 65 years or older on days 0, 7, and 90. This battery allows calculation of a demographically adjusted continuous summary score. Results: Significant practice effects were observed in the CERAD total score and in the word list (learning and recall) subtest. Based on these volunteer data, we developed a threshold for diagnosis of postoperative cognitive dysfunction (POCD) with the CERAD total score. Conclusion: Practice effects with repeated administration of neuropsychological tests must be accounted for in the interpretation of such tests. Ignoring practice effects may lead to an underestimation of POCD. The usefulness of the proposed demographically adjusted continuous score for cognitive function will have to be tested prospectively in patients.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Geriatrie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Geriatrie
03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Anästhesiologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Anästhesiologie
07 Faculty of Psychology > Departement Psychologie
UniBasel Contributors:Monsch, Andreas U and Strebel, Stephan P. and Steiner, Luzius A.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Karger
ISSN:1420-8008
e-ISSN:1421-9824
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:23 Oct 2017 15:02
Deposited On:27 Feb 2014 15:45

Repository Staff Only: item control page