edoc

Conserved regulation of the Caenorhabditis elegans labial/Hox1 gene ceh-13

Streit, Adrian and Kohler, Reto and Marty, Thomas and Belfiore, Marco and Takacs-Vellai, Krisztina and Vigano, Maria-Alessandra and Schnabel, Ralf and Affolter, Markus and Muller, Fritz. (2002) Conserved regulation of the Caenorhabditis elegans labial/Hox1 gene ceh-13. Developmental biology, 242 (2). pp. 96-108.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A5258929

Downloads: Statistics Overview

Abstract

Caenorhabditis elegans contains a set of six cluster-type homeobox (Hox) genes that are required during larval development. Some of them, but unlike in flies not all of them, are also required during embryogenesis. It has been suggested that the control of the embryonic expression of the worm Hox genes might differ from that of other species by being regulated in a lineal rather than a regional mode. Here, we present a trans-species analysis of the cis-regulatory region of ceh-13, the worm ortholog of the Drosophila labial and the vertebrate Hox1 genes, and find that the molecular mechanisms that regulate its expression may be similar to what has been found in species that follow a regulative, non-cell-autonomous mode of development. We have identified two enhancer fragments that are involved in different aspects of the embryonic ceh-13 expression pattern. We show that important features of comma-stage expression depend on an autoregulatory input that requires ceh-13 and ceh-20 functions. Our data show that the molecular nature of Hox1 class gene autoregulation has been conserved between worms, flies, and vertebrates. The second regulatory sequence is sufficient to drive correct early embryonic expression of ceh-13. Interestingly, this enhancer fragment acts as a response element of the Wnt/WG signaling pathway in Drosophila embryos.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell Biology (Affolter)
UniBasel Contributors:Affolter, Markus
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Academic Press
ISSN:1095-564X
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:22 Mar 2018 08:22
Deposited On:22 Mar 2012 13:21

Repository Staff Only: item control page