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Protein-Polymer Supramolecular Assemblies : a Key Combination for Multifunctionality

Palivan, C. G. and Zhang, X. Y. and Meier, W.. (2013) Protein-Polymer Supramolecular Assemblies : a Key Combination for Multifunctionality. Chimia, 67 (11). pp. 791-795.

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Official URL: http://edoc.unibas.ch/dok/A6212306

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Abstract

2D/3D structures resulting from self-assembly of amphiphilic block copolymers can be combined with bioactive compounds, such as proteins and enzymes, to create supramolecular assemblies with specific desired properties and functionality. Chemical tuning of the architecture and properties of supramolecular assemblies to accommodate sensitive biomolecules allows the development of new soft hybrid materials that benefit from the robustness of polymers and from the functionality of biomolecules. The encapsulation/insertion of biomolecules (enzymes, mimics, proteins) in self-assembling block copolymer vesicles enables design of 'nanoreactors' both in solutions and at surfaces for highly diverse applications, ranging from production of antibiotics to creation of artificial organelles. When membrane proteins are inserted into polymer membranes, it is possible to generate functional membranes or active surfaces with a rapid and specific response. In addition, the selective binding of ligand-terminated polymers holds potential for targeted delivery of drugs, or for immobilization on solid support, to provide functional 3D assemblies on an extended surface.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Palivan, Cornelia G and Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Schweizerische Chemische Gesellschaft
ISSN:0009-4293
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:10 Mar 2020 09:42
Deposited On:31 Jan 2014 09:50

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