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c-Ski in health and disease

Bonnon, Carine and Atanasoski, Suzana. (2012) c-Ski in health and disease. Cell & tissue research, 347 (1). pp. 51-64.

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Official URL: http://edoc.unibas.ch/dok/A6212158

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Abstract

c-Ski is an evolutionary conserved protein that is involved in diverse cellular processes such as proliferation, differentiation, transformation, and tumor progression. A large range of cellular partners of c-Ski, including transcription factors, chromatin-remodeling molecules, tumor suppressors, and nuclear hormone receptors, has been identified. Moreover, numerous mechanisms have been described by which c-Ski regulates essential signaling pathways, e.g., the TGFβ pathway. In this review, we summarize the diverse roles attributed to c-Ski during normal development and in cancer progression and discuss future strategies to unravel further the complex nature of c-Ski actions in a context-dependent manner.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Cellular Neurobiology (Atanasoski)
UniBasel Contributors:Atanasoski, Suzana
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:0302-766X
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:26 Sep 2017 07:16
Deposited On:31 Jan 2014 09:50

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